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adult donor islets  (Prodo Labs)

 
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    Prodo Labs adult donor islets
    Adult Donor Islets, supplied by Prodo Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/adult donor islets/product/Prodo Labs
    Average 90 stars, based on 1 article reviews
    adult donor islets - by Bioz Stars, 2026-03
    90/100 stars

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    A, B (A) Islet insulin content and (B) islet apoptosis of normal or <t>T2D</t> human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.
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    A, B (A) Islet insulin content and (B) islet apoptosis of normal or T2D human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.

    Journal: EMBO Molecular Medicine

    Article Title: Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

    doi: 10.15252/emmm.202317928

    Figure Lengend Snippet: A, B (A) Islet insulin content and (B) islet apoptosis of normal or T2D human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.

    Article Snippet: Primary human islets from seven normal and five T2D donors (Appendix Table ) were obtained from Prodo Laboratories, Inc. (Aliso Viejo, CA, USA).

    Techniques: Transduction, Immunostaining, TUNEL Assay, Expressing

    A–C (A) Fasting blood glucose, (B) glucose tolerance, and (C) glucose profiles calculated as AUC of control or STZ‐treated mice transplanted with normal or T2D human islets ( n = 7–8). D Serum human insulin ( n = 7–8). E Representative immunostaining showing insulin/glucagon signal and ELISA measurement of human insulin content in human islet grafts ( n = 4–5). Scale bar = 100 μm. F Representative immunostaining and quantification showing insulin/TUNEL signal in human islet grafts ( n = 5). Scale bar = 100 μm. Data information: Each n represents the measurement of a sample from distinct mice (A–F). One‐way ANOVA (A–F). Data are means ± SEM. AUC, area under the curve; ns, nonsignificant. Source data are available online for this figure.

    Journal: EMBO Molecular Medicine

    Article Title: Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

    doi: 10.15252/emmm.202317928

    Figure Lengend Snippet: A–C (A) Fasting blood glucose, (B) glucose tolerance, and (C) glucose profiles calculated as AUC of control or STZ‐treated mice transplanted with normal or T2D human islets ( n = 7–8). D Serum human insulin ( n = 7–8). E Representative immunostaining showing insulin/glucagon signal and ELISA measurement of human insulin content in human islet grafts ( n = 4–5). Scale bar = 100 μm. F Representative immunostaining and quantification showing insulin/TUNEL signal in human islet grafts ( n = 5). Scale bar = 100 μm. Data information: Each n represents the measurement of a sample from distinct mice (A–F). One‐way ANOVA (A–F). Data are means ± SEM. AUC, area under the curve; ns, nonsignificant. Source data are available online for this figure.

    Article Snippet: Primary human islets from seven normal and five T2D donors (Appendix Table ) were obtained from Prodo Laboratories, Inc. (Aliso Viejo, CA, USA).

    Techniques: Immunostaining, Enzyme-linked Immunosorbent Assay, TUNEL Assay